the bearer laboratory
Home  /  Bearer Research  /  Lab Members  /  Publications  /  Music & Mind  /  Education & Training  /  Links  /  Contact




Publications

  1. Dogra P, Adolphi NL, Wang Z, Lin YS, Butler KS, Durfee PN, Croissant JG, Noureddine A, Coker EN, Bearer EL, Cristini V, Brinker CJ. 2018. Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics. Nat Commun. 2018 Oct 31;9(1):4551. doi: 10.1038/s41467-018-06730-z. PMID: 30382084; PMCID: PMC6208419

  2. Bearer, EL, Manifold-Wheeler, BC, Medina, CS, Gonzales, A, Chaves, F, Jacobs, RE. (2018) Alterations of functional circuitry in aging brain and the impact of mutated APP expression. Neurobiol. Aging 2018 Oct;70:276-290. doi: 10.1016/j.neurobiolaging.2018.06.018. Epub 2018 Jun 28.PMID:30055413

  3. Bearer, EL, Barto, D, Riviere, ARH, Jacobs, RE. (2018) Neural activation imaged by MEMRI in mouse models of PTSD: Early Life Stress and Role of the Serotonergic System in Prolonged Response to Fear. International Society for Magnetic Resonance in Medicine. Med 2120, June 19, 2018, Paris, France, PMID:30349424, PMCID: PMC6195807.

  4. Bearer, EL and Mulligan, BS (2018). Epigenetic changes associated with early life experiences. Current Genomics, Dec;19(8):676-698. doi: 10.2174/1389202919666180307150508. PMID: 30532647

  5. Page-Reeves, J, Regino, L, Murray-Krezan C, Bleecker M, Erhardt E, Burge M, Bearer E, Mishra S. 2017. A comparative effectiveness study of two culturally competent models of diabetes self-management programming for Latinos from low-income households. BMC Endocr Disord. 2017 Jul 24;17(1):46. doi: 10.1186/s12902-017-0192-4. PMID: 28738902. PMCID: PMC5525248

  6. Medina, CS, Manifold-Wheeler, B, Gonzales, A, and Bearer, EL. (2017). Automated computational processing of 3D MR images of mouse brain for phenotyping of living animals. Curr Protoc Mol Biol. 2017 Jul 5;119:29A.5.1-29A.5.38. doi: 10.1002/cpmb.40. PMID:28678440. PMC5457905. Download supplemental materials (.zip file)

  7. Microbes and Alzheimer's Disease. Itzhaki RF, Lathe R, Balin BJ, Ball MJ, Bearer EL, Braak H, Bullido MJ, Carter C, Clerici M, Cosby SL, Del Tredici K, Field H, Fulop T, Grassi C, Griffin WS, Haas J, Hudson AP, Kamer AR, Kell DB, Licastro F, Letenneur L, Lövheim H, Mancuso R, Miklossy J, Otth C, Palamara AT, Perry G, Preston C, Pretorius E, Strandberg T, Tabet N, Taylor-Robinson SD, Whittum-Hudson JA. J Alzheimers Dis. 2016 Mar 8. [Epub ahead of print] No abstract available.

  8. Neuropathology of JC virus infection in progressive multifocal leukoencephalopathy in remission. SantaCruz KS, Roy G, Spigel J, Bearer EL. World J Virol. 2016 Feb 12;5(1):31-7. doi: 10.5501/wjv.v5.i1.31. PMID: 26870672

  9. Towards a Role for Clinical Pathology Diagnostics for Childhood Maltreatment. Bearer EL, Ji J, Trickett P, Kaplan CD, Mennen F. Austin J Clin Pathol. 2015;2(2). pii: 1028. Epub 2015 Sep 29. PMID: 26640822

  10. A simple rapid process for semi-automated brain extraction from magnetic resonance images of the whole mouse head. Delora A, Gonzales A, Medina CS, Mitchell A, Mohed AF, Jacobs RE, Bearer EL. J Neurosci Methods. 2016 Jan 15;257:185-93. doi: 10.1016/j.jneumeth.2015.09.031. Epub 2015 Oct 9. PMID: 26455644

  11. A case of globular glial tauopathy presenting clinically as alzheimer disease. SantaCruz KS, Rottunda SJ, Meints JP, Bearer EL, Bigio EH, McCarten JR. Alzheimer Dis Assoc Disord. 2015 Jan-Mar;29(1):82-4. doi: 10.1097/WAD.0b013e318298e531. No abstract available. PMID: 23751368

  12. Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements.
    Pascal J, Bearer EL, Wang Z, Koay EJ, Curley SA, Cristini V.
    Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14266-71. doi: 10.1073/pnas.1300619110. Epub 2013 Aug 12.
    PMID: 23940372

  13. A Case of Globular Glial Tauopathy Presenting Clinically as Alzheimer Disease.
    Santacruz KS, Rottunda SJ, Meints JP, Bearer EL, Bigio EH, McCarten JR.
    Alzheimer Dis Assoc Disord. 2013 Jun 6. [Epub ahead of print] No abstract available.
    PMID: 23751368

  14. Altered reward circuitry in the norepinephrine transporter knockout mouse.
    Gallagher JJ, Zhang X, Hall FS, Uhl GR, Bearer EL, Jacobs RE.
    PLoS One. 2013;8(3):e57597. doi: 10.1371/journal.pone.0057597. Epub 2013 Mar 4.
    PMID: 23469209

  15. Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.
    Seamster PE, Loewenberg M, Pascal J, Chauviere A, Gonzales A, Cristini V, Bearer EL.
    Phys Biol. 2012 Oct;9(5):055005. doi: 10.1088/1478-3975/9/5/055005. Epub 2012 Sep 25.
    PMID: 23011729

  16. HSV, axonal transport and Alzheimer's disease: in vitro and in vivo evidence for causal relationships.
    Bearer EL.
    Future Virol. 2012 Sep;7(9):885-899.
    PMID: 23335944

  17. Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI.
    Gallagher JJ, Zhang X, Ziomek GJ, Jacobs RE, Bearer EL.
    Neuroimage. 2012 Apr 15;60(3):1856-66. doi: 10.1016/j.neuroimage.2012.01.132. Epub 2012 Feb 10..
    PMID: 22500926

  18. Integrative physical oncology.
    Hatzikirou H, Chauviere A, Bauer AL, Leier A, Lewis MT, Macklin P, Marquez-Lago TT, Bearer EL, Cristini V.
    Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):1-14. doi: 10.1002/wsbm.158. Epub 2011 Aug 18. Review.
    PMID: 21853537

  19. A novel, patient-specific mathematical pathology approach for assessment of surgical volume: Application to ductal carcinoma in situ of the breast.
    Edgerton ME, Chuang YL, Macklin P, Yang W, Bearer EL, Cristini V. Anal Cell Pathol (Amst). 2011 Sep 2. [Epub ahead of print]
    PMID: 21891861

  20. Herpes simplex virus dances with amyloid precursor protein while exiting the cell.
    Cheng SB, Ferland P, Webster P, Bearer EL.
    PLoS One. 2011 Mar 31;6(3):e17966. doi: 10.1371/journal.pone.0017966.
    PMID: 21483850

  21. Physical oncology: a bench-to-bedside quantitative and predictive approach.
    Frieboes HB, Chaplain MA, Thompson AM, Bearer EL, Lowengrub JS, Cristini V.
    Cancer Res. 2011 Jan 15;71(2):298-302. doi: 10.1158/0008-5472.CAN-10-2676. Epub 2011 Jan 11. Review. Erratum in: Cancer Res. 2011 Mar 1;71(5):2024.
    PMID: 21224346

  22. A novel, patient-specific mathematical pathology approach for assessment of surgical volume: application to ductal carcinoma in situ of the breast.
    Edgerton ME, Chuang YL, Macklin P, Yang W, Bearer EL, Cristini V.
    Anal Cell Pathol (Amst). 2011;34(5):247-63. doi: 10.3233/ACP-2011-0019.
    PMID: 21988888

  23. Altered neurocircuitry in the dopamine transporter knockout mouse brain.
    Zhang X, Bearer EL, Boulat B, Hall FS, Uhl GR, Jacobs RE.
    PLoS One. 2010 Jul 9;5(7):e11506. doi: 10.1371/journal.pone.0011506.
    PMID: 20634895

  24. Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child.
    Brown WD, Bearer EL, Donahue JE.
    J Child Neurol. 2010 Jul;25(7):901-8. doi: 10.1177/0883073809353449. Epub 2010 Feb 22. Erratum in: J Child Neurol. 2010 Dec;25(12):1599.
    PMID: 20179002

  25. Increased anatomical detail by in vitro MR microscopy with a modified Golgi impregnation method.
    Zhang X, Bearer EL, Perles-Barbacaru AT, Jacobs RE.
    Magn Reson Med. 2010 May;63(5):1391-7. doi: 10.1002/mrm.22322.
    PMID: 20432310

  26. Germination behavior, biochemical features and sequence analysis of the RACK1/arcA homolog from Phaseolus vulgaris.
    Islas-Flores T, Guillén G, Islas-Flores I, San Román-Roque C, Sánchez F, Loza-Tavera H, Bearer EL, Villanueva MA.
    Physiol Plant. 2009 Nov;137(3):264-80. doi: 10.1111/j.1399-3054.2009.01280.x.
    PMID: 19832940

  27. Reward circuitry is perturbed in the absence of the serotonin transporter.
    Bearer EL, Zhang X, Janvelyan D, Boulat B, Jacobs RE.
    Neuroimage. 2009 Jul 15;46(4):1091-104. doi: 10.1016/j.neuroimage.2009.03.026. Epub 2009 Mar 2
    PMID: 19306930

  28. Multiparameter computational modeling of tumor invasion.
    Bearer EL, Lowengrub JS, Frieboes HB, Chuang YL, Jin F, Wise SM, Ferrari M, Agus DB, Cristini V. Cancer Res. 2009 May 15;69(10):4493-501. doi: 10.1158/0008-5472.CAN-08-3834. Epub 2009 Apr 14.
    PMID: 19366801

  29. Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation.
    Aliotta JM, Sanchez-Guijo FM, Dooner GJ, Johnson KW, Dooner MS, Greer KA, Greer D, Pimentel J, Kolankiewicz LM, Puente N, Faradyan S, Ferland P, Bearer EL, Passero MA, Adedi M, Colvin GA, Quesenberry PJ.
    Stem Cells. 2007 Sep;25(9):2245-56. Epub 2007 Jun 7.
    PMID: 17556595

  30. One at a time, live tracking of NGF axonal transport using quantum dots.
    Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13666-71. Epub 2007 Aug 14.
    PMID: 17698956

  31. Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome.
    Bearer EL, Zhang X, Jacobs RE.
    Neuroimage. 2007 Aug 1;37(1):230-42. Epub 2007 May 18.
    PMID: 17566763

  32. Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth.
    Sanga S, Frieboes HB, Zheng X, Gatenby R, Bearer EL, Cristini V.
    Neuroimage. 2007;37 Suppl 1:S120-34. Epub 2007 Jun 7. Review.
    PMID: 17629503

  33. Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI).
    Bearer EL, Falzone TL, Zhang X, Biris O, Rasin A, Jacobs RE.
    Neuroimage. 2007;37 Suppl 1:S37-46. Epub 2007 May 13.
    PMID: 17600729

  34. Computer simulation of glioma growth and morphology.
    Frieboes HB, Lowengrub JS, Wise S, Zheng X, Macklin P, Bearer EL, Cristini V.
    Neuroimage. 2007;37 Suppl 1:S59-70. Epub 2007 Mar 23.
    PMID: 17475515

  35. A peptide zipcode sufficient for anterograde transport within amyloid precursor protein.
    Satpute-Krishnan P, DeGiorgis JA, Conley MP, Jang M, Bearer EL.
    Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16532-7. Epub 2006 Oct 24.
    PMID: 17062754

  36. Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant.
    Tyszka JM, Readhead C, Bearer EL, Pautler RG, Jacobs RE.
    Neuroimage. 2006 Feb 15;29(4):1058-65. Epub 2005 Oct 5.
    PMID: 16213163

  37. Perspectives on herpes-APP interactions.
    Bearer EL.
    Aging Cell. 2004 Apr;3(2):81-4. No abstract available.
    PMID: 15038824

  38. Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease.
    Satpute-Krishnan P, DeGiorgis JA, Bearer EL.
    Aging Cell. 2003 Dec;2(6):305-18. Erratum in: Aging Cell.2010 Jun;9(3):454.
    PMID: 14677633

  39. Overview of image analysis, image importing, and image processing using freeware.
    Bearer EL.
    Curr Protoc Mol Biol. 2003 Aug;Chapter 14:Unit 14.15. doi: 10.1002/0471142727.mb1415s63.
    PMID: 18265322

  40. The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines.
    Bearer EL, Satpute-Krishnan P.
    Curr Drug Targets Infect Disord. 2002 Sep;2(3):247-64.
    PMID: 12462128

  41. Arp2/3 complex is required for actin polymerization during platelet shape change.
    Li Z, Kim ES, Bearer EL.
    Blood. 2002 Jun 15;99(12):4466-74.
    PMID: 12036877

  42. Association of a nonmuscle myosin II with axoplasmic organelles.
    DeGiorgis JA, Reese TS, Bearer EL.
    Mol Biol Cell. 2002 Mar;13(3):1046-57.
    PMID: 11907281

  43. Actin dynamics in platelets.
    Bearer EL, Prakash JM, Li Z.
    Int Rev Cytol. 2002;217:137-82. Review.
    PMID: 12019562

  44. Motility-related proteins as markers for head and neck squamous cell cancer.
    Abraham MT, Kuriakose MA, Sacks PG, Yee H, Chiriboga L, Bearer EL, Delacure MD.
    Laryngoscope. 2001 Jul;111(7):1285-9.
    PMID: 11568556

  45. Microsequencing of myosins for PCR primer design.
    Bearer EL.
    Methods Mol Biol. 2001;161:9-15. Review. No abstract available.
    PMID: 11190519

  46. VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations.
    Bearer EL, Prakash JM, Manchester RD, Allen PG.
    Cell Motil Cytoskeleton. 2000 Dec;47(4):351-64.
    PMID: 11093254

  47. Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument.
    Bearer EL, Breakefield XO, Schuback D, Reese TS, LaVail JH.
    Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8146-50.
    PMID: 10884436

  48. 2E4/Kaptin (KPTN)--a candidate gene for the hearing loss locus, DFNA4.
    Bearer EL, Chen AF, Chen AH, Li Z, Mark HF, Smith RJ, Jackson CL.
    Ann Hum Genet. 2000 May;64(Pt 3):189-96.
    PMID: 11409409

  49. Squid axoplasm supports the retrograde axonal transport of herpes simplex virus.
    Bearer EL, Schlief ML, Breakefield XO, Schuback DE, Reese TS, LaVail JH.
    Biol Bull. 1999 Oct;197(2):257-8. No abstract available.
    PMID: 10573844

  50. 2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear.
    Bearer EL, Abraham MT.
    Eur J Cell Biol. 1999 Feb;78(2):117-26.
    PMID: 10099934

  51. Association of actin filaments with axonal microtubule tracts.
    Bearer EL, Reese TS.
    J Neurocytol. 1999 Feb;28(2):85-98.
    PMID: 10590510

  52. Primary peptide sequences from squid muscle and optic lobe myosin IIs: a strategy to identify an organelle myosin.
    Medeiros NA, Reese TS, Jaffe H, Degiorgis JA, Bearer EL.
    Cell Biol Int. 1998;22(2):161-73.
    PMID: 9878103

  53. An axoplasmic myosin with a calmodulin-like light chain.
    Bearer EL, DeGiorgis JA, Jaffe H, Medeiros NA, Reese TS.
    Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6064-8.
    PMID: 8650220

  54. Actin-based motility of isolated axoplasmic organelles.
    Bearer EL, DeGiorgis JA, Medeiros NA, Reese TS.
    Cell Motil Cytoskeleton. 1996;33(2):106-14.
    PMID: 8635200

  55. Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells.
    Cheng JC, Frackelton AR Jr, Bearer EL, Kumar PS, Kannan B, Santos-Moore A, Rifai A, Settleman J, Clark JW.
    Cell Growth Differ. 1995 Feb;6(2):139-48.
    PMID: 7756172

  56. Cytoskeletal domains in the activated platelet.
    Bearer EL.
    Cell Motil Cytoskeleton. 1995;30(1):50-66.
    PMID: 7728868

  57. Distribution of Xrel in the early Xenopus embryo: a cytoplasmic and nuclear gradient.
    Bearer EL.
    Eur J Cell Biol. 1994 Apr;63(2):255-68.
    PMID: 8082650

  58. Evidence for myosin motors on organelles in squid axoplasm.
    Bearer EL, DeGiorgis JA, Bodner RA, Kao AW, Reese TS.
    Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11252-6.
    PMID: 8248236

  59. Role of actin polymerization in cell locomotion: molecules and models.
    Bearer EL.
    Am J Respir Cell Mol Biol. 1993 Jun;8(6):582-91. Review.
    PMID: 8323743

  60. An actin-associated protein present in the microtubule organizing center and the growth cones of PC-12 cells.
    Bearer EL.
    J Neurosci. 1992 Mar;12(3):750-61.
    PMID: 1372044]

  61. Actin and actin-associated proteins in Xenopus eggs and early embryos: contribution to cytoarchitecture and gastrulation.
    Bearer EL.
    Curr Top Dev Biol. 1992;26:35-52. Review. No abstract available.
    PMID: 1563278

  62. Cytoskeleton in development. Introduction.
    Bearer EL.
    Curr Top Dev Biol. 1992;26:1-7. No abstract available.
    PMID: 1563274

  63. Direct observation of actin filament severing by gelsolin and binding by gCap39 and CapZ.
    Bearer EL.
    J Cell Biol. 1991 Dec;115(6):1629-38.
    PMID: 1661732

  64. Actin in the Drosophila embryo: is there a relationship to developmental cue localization?
    Bearer EL.
    Bioessays. 1991 Apr;13(4):199-204. Review.
    PMID: 1859400

  65. Morphology of mammalian sperm membranes during differentiation, maturation, and capacitation.
    Bearer EL, Friend DS.
    J Electron Microsc Tech. 1990 Dec;16(4):281-97. Review.
    PMID: 2250184

  66. Platelet membrane skeleton revealed by quick-freeze deep-etch.
    Bearer EL.
    Anat Rec. 1990 May;227(1):1-11.
    PMID: 2368921

  67. Lipids of the platelet membrane.
    Bearer EL, Friend DS.
    Lab Invest. 1986 Feb;54(2):119-21. No abstract available.
    PMID: 3945047

  68. Endothelial fenestral diaphragms: a quick-freeze, deep-etch study.
    Bearer EL, Orci L.
    J Cell Biol. 1985 Feb;100(2):418-28.
    PMID: 3968170

  69. Fusion of phospholipid vesicles arrested by quick-freezing. The question of lipidic particles as intermediates in membrane fusion.
    Bearer EL, Düzgünes N, Friend DS, Papahadjopoulos D.
    Biochim Biophys Acta. 1982 Dec 8;693(1):93-8.
    PMID: 7150597

  70. Modifications of anionic-lipid domains preceding membrane fusion in guinea pig sperm.
    Bearer EL, Friend DS.
    J Cell Biol. 1982 Mar;92(3):604-15.
    PMID: 7085750

  71. beta-Hydroxysterol distribution as determined by freeze-fracture cytochemistry.
    Friend DS, Bearer EL.
    Histochem J. 1981 Jul;13(4):535-46.
    PMID: 6796549

  72. Anionic lipid domains: correlation with functional topography in a mammalian cell membrane.
    Bearer EL, Friend DS.
    Proc Natl Acad Sci U S A. 1980 Nov;77(11):6601-5.