Jain Zhou, M.D., Ph.D.

photo of jain zhou

Assistant Professor

Email: jazhou@salud.unm.edu


Interests:

  • Genitourinary pathology
  • Breast pathology
  • Gynecologic pathology
  • Pathology resident education

Education and Certification Information

Fellowship:
Surgical pathology with genitourinary emphasis
July 2016 - June 2017
Mayo Clinic
Rochester, MN

Residency:
Anatomic and Clinical Pathology
July 2012 -June 2016
University of Texas Medical School at Houston
Houston, TX

Doctorate:
Ph.D. in Pathology
Kyoto University Graduate School of Medicine
Kyoto, Japan
1996

Medical school:
China Medical School
Shenyang, China
1987

Board Certification
The American Board of Pathology (Sub: Anatomical): July 2016
The American Board of Pathology (Sub: Clinical): July 2016

Specialties:

  • Genitourinary Pathology
  • Breast Pathology
  • Gynecologic Pathology

Selected Publications:

  1. Zhou JH, Ashoori F, Suzuki S, Nishigaki I, Yagi K. Protective effect of chlorogenic acid on lipid peroxidation induced in rat by carbon tetrachloride or 60Co-irradiation. J.Clin. Biochem. Nutr. 1993,15:119-125.

  2. Ashoori F, Suzuki S, Zhou JH, Isshiki N, Miyachi Y. Involvement of lipid peroxidation in necrosis of skin flaps and its suppression by ellagic acid. Plast Reconstr Surg. 1994 Dec; 94(7):1027-37.

  3. Nakashima, Y, Iwasa Y, Zhou JH, Toyokuni S, Pataer A. Prostatic Duct Adenocarcinoma (endometrioid carcinoma of the prostate): A case report. Hospital Pathology. 1995 Sep; 12(2):128.

  4. Yamabe H, Zhou JH, Iwasa Y. Endometrial Hyperplasia and Endometrial Carcinoma. Hospital Pathology (in Japanese)1995,12:103-5

  5. Zhou J, Iwasa Y, Konishi I, Kan I, Kannagi R, Kobayashi Y, Kim YC, Yamabe H. Papillary serous carcinoma of the peritoneum in women. Cancer.1995 Aug1; 76(3):429-36.

  6. Ashoori F, Suzuki S, Zhou J, Nishigaki I, Takahashi R. Possible contributions of mastocytosis, apoptosis, and hydrolysis in pathophysiology of randomized skin flaps in humans and guinea pigs. Plast Reconstr Surg. 1996 Sep; 98(3):491-501.

  7. Iwasa Y, Minamiguchi S, Konishi I, Onodera H, Zhou J, Yamabe H. Sclerosing peritonitis associated with luteinized thecoma of the ovary: A case report. Pathol. Int. 1996 Jul; 46(7):510-4.

  8. Benedict WF, Lerner SP, Zhou J, Shen X, Tokunaga H, Czerniak B. Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer. Oncogene. 1999 Feb;18(5):1197-1203.

  9. El-Naggar AK, Lai S, Zhou JH, Tucker SA, Myers J, Luna MA, Benedict WF. Expression of Key cell Cycle Gene (p16, Rb and Cyclin D1) Correlates in Oral and Laryngeal Squamous Carcinoma: Biological and Clinical Implications. Human Pathology. 1999 Sep; 30(9):1013-8.

  10. Navone, NM, Troncoso P, Benedict WF, McDonnell TJ, Rodriguez-Vargas M, Zhou JH, Luthra R, Logothetis CJ. A Model Reflecting Common Molecular Features of Andrigen-dependent Prostate Cancer. Clinical Cancer Res. 2000 Mar; 6(3):1190-1197.

  11. Shinohara H, Zhou J, Tachi M, Yoshikawa K, Yazumi S, Suga KK, Yamaoka Y, Mizukami T, Yoshida T, Benedict WF, Takahashi R. Retinoblastoma Protein Initiates Cellular Growth Arrest that Overcomes the Ability of Cotransfected Wild-Type p53 to Accelerate Apoptosis. British J. Cancer. 2000 Oct; 83(8):1039-46.

  12. Nguyen, C, Liang G, Nguyen TT, Wei DS, Groshen S, Lubbert M, Zhou JH, Benedict WF, Jones PA. Increased Susceptibility of Non-Promoter CpG Islands to De Novo Methylation in Normal and Neoplastic Cells. J. Natl. Cancer Inst. 2001 Mar; 93(19):1465-1472.

  13. Tokunaga H, Shariat SF, Green AE, Brown RM, Zhou JH, Benedict WF, Lerner SP. Correlation of Immunohistochemical Molecular Staging of Bladder Biopsies and Radical Cystectomy Specimens. Int.J.Radial.Oncol.Biol.Phys.2001 Sep 1; 51(1):16-22.

  14. Yamashita M, Rosser CJ, Zhou JH, Zhang X, Connor RJ, Engler H, Maneval DC, Karashima T, Czerniak BA, Dinney CP, Benedict WF. Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer. Cancer Gene Therapy. 2002 Aug; 9(8):687-91.

  15. Zhou JH, Rosser CJ, Tanaka M, Yang M, Baranov E, Hoffman RM, Benedict WF. Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression. Cancer Gene Therapy. 2002 Aug; 9(8):681-6.

  16. Zhang X, Multani AS, Zhou JH, Shay JW, McConkey D, Dong L, Kim C, Rosser CJ, Pathak S, Benedict WF. Adenoviral-mediated Retinoblastoma 94 Produce Rapid Telomere Erosion, Chromosomal Crisis, and Caspase-dependent Apoptosis in Bladder Cancer and Immortalized Human Urothelial Cells but not in Normal Urothelial Cells. Cancer Research. 2003 Feb 15; 63 (3):760-5.

  17. Shariat SF, Matsumoto K, Kim J, Ayala GE, Zhou JH, Jian W, Benedict WF, Lerner SP. Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder. J Urol. 2003 Sep; 170(3):985-9.

  18. Tanaka M, Gee JR, De La Cerda J, Rosser CJ, Zhou JH, Benedict WF, Grossman HB. Noninvasive Detection of Bladder Cancer in An Orthotopic Murine Model with Green Fluorescence Protein Cytology. J Urol. 2003 Sep; 170(3):975-8.

  19. Benedict WF, Tao Z, Kim CS, Zhang X, Zhou JH, Adam L, McConkey DJ, Papageorgiou A, Munsell M, Philopena J, Engler H, Demers W, Maneval DC, Dinney CP, Connor RJ. Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein. Mol Ther. 2004 Sep;10(3):525-32.

  20. Shariat SF, Tokunaga H, Zhou J, Kim JH, Ayala GE, Benedict WF, Lerner SP. P53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Oncol. 2004 Mar15;22(6):1014-24.

  21. Sabichi A, Keyhani A, Tanaka N, Delacerda J, Lee IL, Zou C, Zhou JH, Benedict WF, Grossman HB. Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression. J Urol. 2006 Mar; 175(3 Pt 1):1133-7.

  22. Lee S, Jeong J, Majewski T, Scherer SE, Kim MS, Tuziak T, Tang KS, Baggerly K, Grossman HB, Zhou JH, Shen L, Bondaruk J, Ahmed SS, Samanta S, Spiess P, Wu X, Filipek S, McConkey D, Bar-Eli M, Issa JP, Benedict WF, Czerniak B. Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13732-7.

  23. Pirollo KF, Rait A, Zhou Q, Zhang XQ, Zhou J, Kim CS, Benedict WF, Chang EH. Tumor-targeting nanocomplex delivery of novel tumor suppressor RB94 chemosensitizes bladder carcinoma cells in vitro and in vivo. Clin Cancer Res. 2008 Apr 1; 14(7):2190-8.

  24. Majewski T, Lee S, Jeong J, Yoon DS, Kram A, Kim MS, Tuziak T, Bondaruk J, Lee S, Park WS, Tang KS, Chung W, Shen L, Ahmed SS, Johnston DA, Grossman HB, Dinney CP, Zhou JH, Harris RA, Snyder C, Filipek S, Narod SA, Watson P, Lynch HT, Gazdar A, Bar-Eli M, Wu XF, McConkey DJ, Baggerly K, Issa JP, Benedict WF, Scherer SE, Czerniak B. Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. Lab Invest. 2008 Jul; 88(7):694-721.

  25. Zhou J, Zhang X-Q, Ashoori F, Dong L, McConkey, DJ, Benedict WF. .Early RB94-produced cytotoxicity in Cancer Cells is independent of caspase activation or 50 kb DNA fragmentation. Cancer Gene Therapy. 2009 Jan;16(1):13-19.

  26. Liang L, Zhou J, Chen L. Perifollicular granulomas with IgG4 plasmacytosis: A case report and review of literature.World J Clin Cases. 2015 Jul 16;3(7):650-4.

  27. Liu YY, Hoang TK, Wang T, He B, Tran DQ, Zhou J, Tatevian N, Marc J. Circulating L-selectin expressing-T cell subsets correlate with the severity of Foxp3 deficiency autoimmune disease. Int J Clin Exp Pathol 2016;9(2):899-909

  28. He B, Hoang T,Wang T, Ferris M, Taylor C, Tian T, Luo M, Tran D, Zhou J, Nina Tatevian N, Luo F, Molina J, Blackburn M, Gomez T, Roos S, Rhoads J, and Liu YY. Resetting microbiota by Lactobacillus reuteri inhibits Treg deficiency-induced autoimmunity via adenosine A2A receptors. J. Exp. Med. 2017; 214(1):107

  29. Zhou J and Covinsky M. Sclerosing Pneumocytoma: A Carcinoma Mimicker. 2016. Ann Clin Lab Sci. January-February 2017, Vol. 47 no. 1 103-105

  30. Cherian SV, Martin RM, Irani AD, Zhou J, and Weissferdt A. A 33-Year-Old Woman with a Fluorodeoxyglucose Glucose Avid left Lower Lobe mass. Chest. 2017 May;151(5):e119-e122

  31. A Varkaris, PG. Corn, E Efstathiou, NU. Parikh JH. Song, YC Lee, J Zhou, A Aparicio, AG. Hoang, S Gaur, L Thorpe, SN Maity, MB Eli, BA. Czerniak MD , SH Lin, CJ. Logothetis, and GE. Gallick. Integration of Murine and Clinical Trials Links Modulation of the Tumor- associated Microenvironment with Cabozantinib Efficacy in Metastatic Castrate Resistant Prostate Cancer. Submitted