Dennis J. McCance, Ph.D.

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Research Professor

Phone: 505-272-0624


  • Rb function in the tumour microenvironment
  • Myofibroblasts and Rb function in tumours
  • p63 in cancer and keratinocyte differentiation

Education and Certification Information

Howard Hughes Fellowship
University of Chicago
Chicago, IL

University of Birmingham
Mentor, Dr. Robert Drysdale
Birmingham, England

BSc (Microbiology Honours)
Queen's University Belfast
Belfast, Ireland

BSc (Zoology)
Queen's University Belfast
Belfast, Ireland

Selected Publications:

  • Schache AG, Powell NG, Cuschieri KS, Robinson M, Leary S, Mehanna H, Rapozo D, Long A, Cubie H, Junor E, Monaghan H, Harrington KJ, Nutting CM, Schick U, Lau AS, Upile N, Sheard J, Brougham K, West CM, Oguejiofor K, Thomas S, Ness AR, Pring M, Thomas GJ, King EV, McCance DJ, James JA, Moran M, Sloan P, Shaw RJ, Evans M, Jones TM. HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology. Cancer Res. 2016 Aug 28. [Epub ahead of print] PMID:27569214

  • Pickard A, McDade SS, McFarland M, McCluggage WG, Wheeler CM, McCance DJ. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015 Jun 24;11(6):e1004988. doi: 10.1371/journal.ppat.1004988. eCollection 2015 Jun. PMID:26107517

  • Srivastava K, Pickard A, McDade S, McCance DJ. p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling. Oncotarget. 2015 May 7. [Epub ahead of print] PMID:26001294

  • Pickard A, McCance DJ. IGF-Binding Protein 2 - Oncogene or Tumor Suppressor? Front Endocrinol (Lausanne). 2015 Feb 27;6:25. doi: 10.3389/fendo.2015.00025. eCollection 2015. Review. PMID:25774149

  • McDade, SS., Patel, D., Moran, M., Campbell, J., Orr, NJ., Fenwick, K., Kozarewa, I., Lord, CJ., Ashworth, A., McCance, DJ. (2014) Genome wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress. Nucl. Acid Res. 42(10):6270-85. 6270-85. doi:10.1093/nar/gku299

  • McKenna, DJ, Patel, D., McCance, DJ (2013) miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes. Virology 79: 210-216.

  • Cichon, A-C*., Pickard, A*, McDade, SS., Sharpe, DJ., Moran, M., James, JA., McCance, DJ (2013) AKT in stromal fibroblasts controls invasion of epithelial cells. Oncotarget 4: 1103-1116
    * = joint first authors

  • Adam Pickard, Ann-Christin Cichon, Craig Menges, Daksha Patel and Dennis McCance (2012) Regulation of epithelial differentiation and proliferation by the stroma – a role for the retinoblastoma protein. J Invest. Dermatol. 14 June 2012; doi:10.1038/jid.2012.201

  • McDade, SS. Henry, A. Pivato, GP. Fenwick, K. Assiotis, I. Kozarewa, I. Mitsopoulos, C. Hakas, J. Zvelebil, M. Orr, N. Lord, CJ. Ashworth, A. Patel, D. McCance, DJ. (2012) Genome wide identification of p63 binding sites reveals co-association of AP-2α on regulatory regions of genes required for palatal fusion. Nucleic Acid Res. 40(15):7190-206. doi:10.1093/nar/gks389

  • Adam Pickard, Ann-Christin Cichon, Anna Barry, Declan Kieran, Daksha Patel, Peter Hamilton, Manuel Salto-Tellez, Jacqueline James and Dennis J. McCance. (2012) Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion. EMBO J. 29 May 2012; 31(14):3092-103 doi:10.1038/emboj.2012.153

  • Hyland, PL, McDade, SS., McCloskey, R., Dickson, GJ., Arthur, K., McCance, DJ., Patel, D. (2011) Evidence for Alteration of EZH2, BMI1 and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type-16 E6/E7 Expressing Keratinocytes. J. Virol. 85: 10999-11006. PMID: 21865393

  • Buckley NE, Conlon SJ, Jirstrom K, Kay EW, Crawford NT, O'Grady A, Sheehan K, Mc Dade SS, Wang CW, McCance DJ, Johnston PG, Kennedy RD, Harkin DP, Mullan PB. (2011) The {Delta}Np63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer. Cancer Res. ;71(5): 1933-44. PMID: 21363924.

  • McDade, SS., Patel, D., McCance, DJ. (2011) p63 maintains proliferative capacity through control of Skp2/p130. J. Cell Sci. 123: 3718-3726. PMID: 21511729

  • Lindsay, J., McDade, SS., Pickard, A., McCloskey, K., McCance, DJ (2011) The role of np63 in epithelial to mesenchymal transition. J. Biol. Chem. 286: 3915-3924 PMID: 21127042.

  • Patel, D., McCance, DJ. (2010) Compromised Spindle Assembly Checkpoint due to Altered Expression of Ubch10 and Cdc20 in Human Papillomavirus Type 16 E6 and E7-Expressing Keratinocytes. J. Virology 84: 10956-10964.

Search PubMed:

Dennis J. McCance on PubMed