Angela Wandinger-Ness, Ph.D.

photo of angela wandinger-ness

The Victor and Ruby Hansen Surface Endowed Professor in Cancer Cell Biology and Clinical Translation

Director, Fluorescence Microscopy Shared Resource

PI, Academic Science Education and Research Training Program

Lab website: The Wandinger-Ness Laboratory
Fluorescence Microscopy Shared Resource
Academic Science Education and Research Training Program

Research Interests:

  • GTPases as targets of small molecules therapeutics for ovarian cancer and genetic diseases
  • Cellular & molecular basis of autosomal dominant polycystic kidney disease
  • Renal stem cells
  • Interrelationships between membrane trafficking, signaling cell polarity and disease pathology
  • Molecular mechanisms of Rab GTPases and lipid signaling in membrane trafficking

Education Interests:

  • Skill building and career development through cross-training in research and education
  • Development of training programs that build diversity in research and education

Education and Certification Information

Post-Doctoral Training Fellowship:
Cell Biology Programme
European Molecular Biology Laboratory
Heidelberg, FRG

University of California
Los Angeles, California

University of Massachusetts
Amherst, Massachusetts

Selected Publications:


  • de Almeida RM, Clendenon SG, Richards WG, Boedigheimer M, Damore M, Rossetti S, Harris PC, Herbert BS, Xu WM, Wandinger-Ness A, Ward HH, Glazier JA, Bacallao RL. Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD. Hum Genomics. 2016 Nov 21;10(1):37. PMID:27871310

  • Wang H, Leung M, Wandinger-Ness A, Hudson LG, Song M. Constrained inference of protein interaction networks for invadopodium formation in cancer. IET Syst Biol. 2016 Apr;10(2):76-85. doi: 10.1049/iet-syb.2015.0009.PMID:26997662

  • Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A.  (2015) Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182. doi: 10.1371/journal.pone.0142182. eCollection 2015. PMID:26558612

  • Uzarski JS, Su J, Xie Y, Zhang ZJ, Ward HH, Wandinger-Ness A, Miller WM, Wertheim JA.  (2015) Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development. J Vis Exp. 2015 Aug 10;(102):e53271. doi: 10.3791/53271. PMID:26327609

  • Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, Schroeder CE, Simons P, Waller A, Garcia M, Carter M, Ursu O, Gouveia K, Golden JE, Aubé J, Wandinger-Ness A, Sklar LA.  (2015) A Pan-GTPase Inhibitor as a Molecular Probe. PLoS One. 2015 Aug 6;10(8):e0134317. doi: 10.1371/journal.pone.0134317. eCollection 2015. PMID:26247207

  • Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A. (2015) R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. Mol Cancer Ther. 2015 Oct;14(10):2215-27. doi: 10.1158/1535-7163.MCT-15-0419. Epub 2015 Jul 23. PMID:26206334

  • Guo Y, Kenney SR, Cook L, Adams SF, Rutledge T, Romero E, Oprea TI, Sklar LA, Bedrick E, Wiggins CL, Kang H, Lomo L, Muller CY, Wandinger-Ness A, Hudson LG. A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients. Clin Cancer Res. 2015 Nov 15;21(22):5064-72. doi: 10.1158/1078-0432.CCR-15-0461. Epub 2015 Jun 12. PMID:26071482

  • Uzarski JS, Bijonowski BM, Wang B, Ward HH, Wandinger-Ness A, Miller WM, Wertheim JA.  (2015) Dual-Purpose Bioreactors to Monitor Noninvasive Physical and Biochemical Markers of Kidney and Liver Scaffold Recellularization. Tissue Eng Part C Methods. 2015 Oct;21(10):1032-43. doi: 10.1089/ten.TEC.2014.0665. Epub 2015 Jun 26. PMID:25929317

  • Agola JO, Sivalingam D, Cimino DF, Simons PC, Buranda T, Sklar LA, Wandinger-Ness A. (2015) Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein. Methods Mol Biol. 2015;1298:331-54. doi: 10.1007/978-1-4939-2569-8_28. PMID:25800855

  • Hong, L., Z. Surviladze, S.R. Kenney, G.K. Phillips, D. Simpson, C.E. Schroeder, J. Nöth, E. Romero, T. Buranda, A. Waller, O. Ursu, J.J. Strouse, J.E. Golden, J. Aubé, L.G. Hudson, L.A. Sklar and A. Wandinger-Ness. (2013) Identification and Characterization of a Cdc42 GTPase Selective Inhibitor. J Biol. Chem. 288:1135-49. PMC3542998. (Impact factor: 4.77). Article chosen for feature by SciBX. UNM Cancer Center Press Release and under consideration for Nature News and Views feature.

  • Herbert, B.-S., B.R. Grimes, W.M. Xu, M. Werner, C. Ward, S. Rossetti, P. Harris, E. Bello-Reuss, H.H. Ward, C. Miller, V.H. Gattone, C.L. Phillips, A. Wandinger-Ness and R. Bacallao. (2013) A Telomerase Immortalized Human Proximal Tubule Cell Line with a Truncation Mutation (Q4004X) in Polycystin-1. PLoS One, 8(1):e55191. PMC3557233 (Impact factor: 4.09).

  • BasuRay, S., S. Mukherjee, E. Romero, M.N.J. Seaman and A. Wandinger-Ness. (2013) Rab7 Mutants Associated with Charcot-Marie-Tooth Disease Cause Delayed Growth Factor Receptor Transport and Altered Endosomal and Nuclear Signaling. J. Biol. Chem. 288:1135-1149. PMC3542998 [Available on 2014/1/11]. (Impact factor: 4.77). Cited by Faculty of 1000: Li G: F1000Prime Recommendation of [BasuRay S et al., J Biol Chem 2013, 288(2):1135-49]. In F1000Prime, 22 Jan 2013

  • Stein, M-P., M. Müller and A. Wandinger-Ness. (2012) Commandeering Rabs allows bacterial pathogens to establish intracellular niches. Invited review. Traffic: doi: 10.1111/tra.12000. 13:1565-1588. Special Series on Pathogen-Host Cell Interactions. PMC3530015 [Available on 2014/2/17]

  • Agola, J.O., L. Hong, Z. Surviladze, T. Buranda, O. Ursu, A. Waller, J.J. Strouse, D.S. Simpson, C.E. Schroeder, J.E. Golden, T.I. Oprea, J. Aubé, L.A. Sklar and A. Wandinger-Ness. (2012) A Competitive Nucleotide Binding Inhibitor: In vitro Characterization of Rab7 GTPase Inhibition. ACS Chemical Biology. 7:1095-108. PMC3440014 [Available on 2013/6/15]. (Impact factor: 6.446)

  • Chavez, M., C. Buhr, W. Petri, A. Wandinger-Ness, D. Kusewitt and L. Hudson. (2012) Differential Downregulation of E-cadherin and Desmoglein by Epidermal Growth Factor. Dermatology Research and Practice. 2012:309587. PMC3270554.


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