Karen S. SantaCruz, M.D.

photo of Karen SantaCruz

Associate Professor

Email: KSantaCruz@salud.unm.edu


Interests:

  • Anatomic Pathology
  • Neuropathology
  • Neurodegenerative diseases
  • Gliomagenesis and immunotherapy
  • Ischemia-reperfusion after cardiac resuscitation
  • Traumatic brain injury

Education and Certification Information

Internship and Residency:
Anatomic Pathology and Neuropathology
University of California Irvine Medical Center
Orange, CA
1993-1998

M.D.
School of Medicine
University of Arizona
Tucson, AZ
1993

Board Certifications:
Board certified Anatomic Pathology and Neuropathology
American Board of Pathology
1999

B.S.
Ecology and Evolutionary Biology
University of Arizona
Tucson, AZ
1985


Selected Publications:

  • Karen S. SantaCruz MD, Joshua A. Sonnen MD, Maryam Kherad Pezhouh MD, Mark F. Desrosiers PhD, Peter T. Nelson MD,PhD, Suzanne L. Tyas PhD. Alzheimer’s Disease Pathology without Dementia in two Studies of Aging: The Nun Study and the Adult Changes in Thought Study. JNEN. Volume 70, Number 10, October 2011.

  • Joshua A. Sonnen, MD; Karen SantaCruz, MD; Laura S. Hemmy, PhD; Randall Woltjer, MD, PhD; James B. Leverenz, MD;Kathleen S. Montine, PhD; Clifford R. Jack, MD; Jeffrey Kaye, MD; Kelvin Lim, MD; Eric B. Larson, MD, MPH; Lon White, MD,MPH; Thomas J. Montine, MD, PhD. Ecology of the Aging Human Brain. ARCH NEUROL/VOL 68 (NO. 8), AUG 2011

  • Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, SantaCruz KS, Sonnen JA,Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain. 2011 May;134(Pt 5):1506-18.

  • Abner, Erin L.1, MPH, Kryscio, Richard J. 1,2 PhD, Schmitt, Frederick A. 1,3, PhD, SantaCruz, Karen S. 4, MD, Jicha,Gregory A. 1,3, MD PhD, Lin, Yushun 1,2, Janna M. Neltner6, MD, Smith, Charles D.1,3, MD, Van Eldik, Linda J. 1,5 PhD, Nelson, Peter T.1, 6, MD PhD. “End-stage” neurofibrillary tangle pathology in preclinical Alzheimer’s disease—fact or fiction? J Alzheimers Dis. 2011 Jan 1;25(3):445-53.

  • Olin MR, Andersen BM, Zellmer DM, Grogan PT, Popescu FE, Xiong Z, Forster CL, Seiler C, SantaCruz KS, Chen W, Blazar BR, Ohlfest JR. Superior Efficacy of Tumor Cell Vaccines Grown In Physiologic Oxygen. Clin Cancer Res. 2010 Sep 21.

  • Swaminathan SK, Olin MR, Forster CL, SantaCruz KS, Panyam J, Ohlfest JR. Identification of a novel monoclonal antibody recognizing CD133. J Immunol Methods. 2010 Jul 30. [Epub ahead of print]

  • Wiesner SM, Decker SA, Larson JD, Ericson K, Forster C, Gallardo JL, Long C, Demorest ZL, Zamora EA, Low WC, SantaCruz K, Largaespada DA, Ohlfest JR. De novo induction of genetically engineered brain tumors in mice using plasmid DNA. Cancer Res. 2009 Jan 15;69(2):431-9.

  • Pluhar GE, Grogan PT, Seiler C, Goulart M, SantaCruz KS, Carlson C, Chen W, Olin MR, Lowenstein PR, Castro MG, Haines SJ, Ohlfest JR. Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. Vaccine. 2010 Apr 26;28(19):3371-8. Epub 2010 Mar 1.

  • Lee MS, McKinney AM, Brace JR, SantaCruz K. Clinical and imaging features of fludarabine neurotoxicity. J Neuroophthalmol. 2010 Mar;30(1):37-41.

  • McKinney AM, Kieffer SA, Paylor RT, SantaCruz KS, Kendi A, Lucato L. Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging. AJR Am J Roentgenol. 2009 Jul;193(1):192-206.

  • SantaCruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH. Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005 Jul 15;309(5733):476-81.

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Karen S. SantaCruz on PubMed