Janet M. Oliver, Ph.D.

photo of Janet Oliver

Regents' Professor Emerita

Founding Director, New Mexico Center for Spatiotemporal Modeling of Cell Signaling

PI and Director, New Mexico Cancer Nanotechnology Training Center

Associate Director Emerita, UNM Cancer Center

Email: JOliver@salud.unm.edu
Lab Website: The Oliver Laboratory
STMC: stmc.health.unm.edu
CNTC: cntc.unm.edu

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The Oliver Laboratory has focused since 1973 on the integration of novel imaging technologies with quantitative biochemical measurement and computational modeling to better understand membrane dynamics and the role of membrane protein mobility in the regulation of complex signaling pathways in immune and cancer cells.

Current interests include:

  • Cell and Systems Biology
  • Cell membrane organization and function
  • Tyrosine kinase signaling pathways
  • Spatial and temporal modeling of signaling pathways
  • Application of nanoparticles for molecular imaging and drug delivery

Education and Certification Information

Postdoctoral Fellow
Department of Physiology
Harvard Medical School

Ph.D. (Biochemistry)
The Courtauld Institute of Biochemistry
Middlesex Hospital Medical School
University of London, U.K.

M.Sc. (Biochemistry)
NCI Canada Cancer Research Unit
University of Alberta, Canada

B.Sc. Honors (Biochemistry)
School of Biological Sciences
Flinders University of South Australia

B.Sc. (Biochemistry and Zoology)
University of Adelaide, South Australia

Selected Publications:

  • Espinoza, FA, JM Oliver, BS Wilson, SL Steinberg. Using Hierarchical Clustering and Dendrograms to Quantify the Clustering of Membrane Proteins. Bull. Math. Biol. 2012:74; 190-211.

  • Espinoza, FA, MJ Wester, JM Oliver, BS Wilson, NL Andrews, DS Lidke and SL Steinberg. Insights Into Cell Membrane Microdomain Organization from Live Cell Single Particle Tracking of the IgE High Affinity Receptor FcεRI of Mast Cells. Bull. Math. Biol. 2012: 74; 1857-1911.

  • Wilson, BS, J.M. Oliver, D.S. Lidke. Spatiotemporal signaling in mast cells. In: Mast Cell Biology, Contemporary and Emerging Topics, Editors, Dean Metcalfe and Alasdair Gilfillan. Landes BioScience and Springer Science. 2011; 716: 91-106.

  • Oliver, JM, C Tarleton, L Gilmartin, T Archibeque, CR Qualls, L Diehl, BS Wilson and M Schuyler. Reduced FcɛRI-mediated release of asthma-promoting cytokines and chemokines from human basophils during Omalizumab therapy. Int. Arch. Allergy. Immunol. 2010; 151:275-284.

  • Carroll-Portillo, A, K Spendier, J Pfeiffer, G Griffiths, H Li, JM Oliver, D Lidke, J Thomas, BS Wilson and J Timlin. FcεRI Membrane Dynamics upon Binding Mobile or Immobile Ligands on Surfaces: Formation of a Mast Cell Synapse. J Immunol. 2010; 184:1328-38.

  • Radhakrishnan, K, J Edwards, D Lidke, T Jovin, B Wilson, and J Oliver. Sensitivity Analysis Predicts that the ERK-pMEK Interaction Regulates ERK Nuclear Translocation. IET Systems Biology 2009; 3: 329-341.

  • Andrews, NL, JR. Pfeiffer, AM Martinez, DM Haaland, RW Davis, JM Oliver, BS Wilson and DS Lidke. Small, mobile FcɛRI aggregates are signaling competent. Immunity. 2009; 31:469–479.

  • Andrews, NL, KA Lidke, JR. Pfeiffer, AR Burns, BS Wilson, JM Oliver, and DS Lidke. Actin restricts FcεRI diffusion and facilitates antigen-induced receptor immobilization. Nature Cell Biol. 2008; 10: 955-963.

  • Lidke, DS, NL Andrews, KA Lidke, JR Pfeiffer, HDT Jones, MB Sinclair, DM Haaland, AR Burns, BS Wilson and JM Oliver. 2007. Exploring membrane protein dynamics by multicolor single quantum dot imaging using wide field, TIRF, and hyperspectral microscopy. Proc. SPIE 6448: 64480Y1-8.

  • Torigoe, C, JR. Faeder, JM Oliver and B Goldstein. 2007. Kinetic proofreading of ligand-FceRI interactions persists beyond LAT phosphorylation. J. Immunol. 178: 3530 - 3535.

  • Zhang, J, K Leiderman, JR Pfeiffer, BS Wilson, JM Oliver and SL Steinberg. 2006. Characterizing the topography of membrane receptors and signaling molecules from spatial patterns obtained using nanometer-scale electron –dense probes and electron microscopy. Micron. 37: 14-34.

  • Frankel, DJ, JR Pfeiffer, JM Oliver, BS Wilson and AR Burns. 2006. FcɛRI signaling domains observed as distinct topographic features on the inside of mast cell membranes. Biophys. J. 90: 2404–2413.

  • Hernandez-Hansen,V, JDJ Bard, JA Wilder, CA Lowell, BS Wilson and JM Oliver. 2005. Increased expression of genes linked to FceRI signaling and to chemokine and cytokine production in Lyn-deficient mast cells. J. Immunol. 175: 7880 - 7888.

  • Wilson, BS, SL Steinberg, K Liederman, JR Pfeiffer, Z Surviladze, J Zhang, LE Samelson, LH Yang, PG Kotula, and JM Oliver. 2004. Markers for Detergent-Resistant Lipid Rafts Occupy Distinct and Dynamic Domains in Native Membranes. Mol. Biol Cell. 15: 2580-2592.

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Janet M. Oliver on PubMed