Cheryl L. Willman, M.D.

photo of Cheryl Willman

Distinguished Professor of Pathology and Internal Medicine

The Maurice and Marguerite Liberman Distinguished Endowed Chair in Cancer Research

Director & CEO, UNM Comprehensive Cancer Center

Email: CWillman@salud.unm.edu
Lab Website: The Willman Laboratory


Interests:

  • Leukemia Genetics and Genomics
  • Discovery of Underlying Genetic Mutations in Leukemia Through Next Generation Sequencing Methods and Development of Diagnostics and Targeted Therapies
  • Hematopathology
  • Nanotechnology and Nanotherapeutics

Big questions:

  • What are the molecular alterations that lead to leukemia?
  • How will genomics and next generation sequencing be applied to leukemia diagnostics and therapeutics to improve patient outcomes?

Model systems:

  • Primary human leukemia samples (Children’s Oncology Group (COG) and UNM Tissue Banks)
  • Mouse xenograft models of human leukemia

Methodology:

  • Gene expression arrays, comprehensive genomic platforms, next generation sequencing methods, bioinformatics

Education and Certification Information

Fellowship:
UNM School of Medicine and University of Washington (July 1985)
Specialty in Pathology

Internship AND Residency Combined:
UNM School of Medicine (July 1984)
Specialty in Anatomical Pathology

Medical School:
Mayo Medical School (July 1981)

Board Certifications:
Am Bd Pathology (Sub: Anatomical) : (January 1986)

Specialties:
Anatomic Pathology, Hematopathology, Molecular Pathology


Selected Publications:

  • Jain N, Roberts KG, Jabbour E, Patel K, Eterovic AK, Chen K, Zweidler-McKay P, Lu X, Fawcett G, Wang SA, Konoplev S, Harvey RC, Chen IM, Payne-Turner D, Valentine M, Thomas D, Garcia-Manero G, Ravandi F, Cortes J, Kornblau S, O'Brien S, Pierce S, Jorgensen J, Shaw KR, Willman CL, Mullighan CG, Kantarjian H, Konopleva M. Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults. Blood. 2016 Dec 5. pii: blood-2016-07-726588. [Epub ahead of print] PMID:27919910

  • Roberts KG, Gu Z, Payne-Turner D, McCastlain K, Harvey RC, Chen IM, Pei D, Iacobucci I, Valentine M, Pounds SB, Shi L, Li Y, Zhang J, Cheng C, Rambaldi A, Tosi M, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Wiernik PH, Bhatia R, Aldoss I, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Mullighan CG. High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults. J Clin Oncol. 2016 Nov 21:JCO2016690073. [Epub ahead of print] PMID:27870571

  • Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I, Shao Y, Chen IM, Valentine M, Pei D, Mungall KL, Mungall AJ, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster JM, Devidas M, Dai Y, Wood B, Borowitz M, Larsen EE, Maloney K, Mattano LA Jr, Angiolillo A, Salzer WL, Burke MJ, Gianni F, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, L Loh M, P Hunger S, Mullighan CG. Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia. Nat Commun. 2016 Nov 8;7:13331. doi: 10.1038/ncomms13331. PMID:27824051

  • Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IL, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrózek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nat Genet. 2016 Dec;48(12):1481-1489. doi: 10.1038/ng.3691. PMID:27776115

  • Davidson NE, Armstrong SA, Coussens LM, Cruz-Correa MR, DeBerardinis RJ, Doroshow JH, Foti M, Hwu P, Kensler TW, Morrow M, Mulligan CG, Pao W, Platz EA, Smith TJ, Willman CL. AACR Cancer Progress Report 2016. Clin Cancer Res. 2016 Oct 1;22(19 Supplement):S1-S137. No abstract available. PMID:27697776

  • Durfee PN, Lin YS, Dunphy DR, Muñiz AJ, Butler KS, Humphrey KR, Lokke AJ, Agola JO, Chou SS, Chen IM, Wharton W, Townson JL, Willman CL, Brinker CJ. Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells. ACS Nano. 2016 Sep 27;10(9):8325-45. doi: 10.1021/acsnano.6b02819. PMID:27419663

  • Zaliova M, Moorman AV, Cazzaniga G, Stanulla M, Harvey RC, Roberts KG, Heatley SL, Loh ML, Konopleva M, Chen IM, Zimmermannova O, Schwab C, Smith O, Mozziconacci MJ, Chabannon C, Kim M, Frederik Falkenburg JH, Norton A, Marshall K, Haas OA, Starkova J, Stuchly J, Hunger SP, White D, Mullighan CG, Willman CL, Stary J, Trka J, Zuna J. Characterization of leukemias with ETV6-ABL1 fusion. Haematologica. 2016 Sep;101(9):1082-93. doi: 10.3324/haematol.2016.144345. PMID:27229714

  • Larsen EC, Devidas M, Chen S, Salzer WL, Raetz EA, Loh ML, Mattano LA Jr, Cole C, Eicher A, Haugan M, Sorenson M, Heerema NA, Carroll AA, Gastier-Foster JM, Borowitz MJ, Wood BL, Willman CL, Winick NJ, Hunger SP, Carroll WL. Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group Study AALL0232. J Clin Oncol. 2016 Jul 10;34(20):2380-8. doi: 10.1200/JCO.2015.62.4544. PMID:27114587

  • Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2016 Jun 2;534(7605):138. doi: 10.1038/nature16997. No abstract available. PMID:26958840

  • Iacobucci I, Li Y, Roberts KG, Dobson SM, Kim JC, Payne-Turner D, Harvey RC, Valentine M, McCastlain K, Easton J, Yergeau D, Janke LJ, Shao Y, Chen IM, Rusch M, Zandi S, Kornblau SM, Konopleva M, Jabbour E, Paietta EM, Rowe JM, Pui CH, Gastier-Foster J, Gu Z, Reshmi S, Loh ML, Racevskis J, Tallman MS, Wiernik PH, Litzow MR, Willman CL, McPherson JD, Downing JR, Zhang J, Dick JE, Hunger SP, Mullighan CG. Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia. Cancer Cell. 2016 Feb 8;29(2):186-200. doi: 10.1016/j.ccell.2015.12.013. PMID:26859458

  • Tricoli JV, Blair DG, Anders CK, Bleyer WA, Boardman LA, Khan J, Kummar S, Hayes-Lattin B, Hunger SP, Merchant M, Seibel NL, Thurin M, Willman CL. Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma. Cancer. 2016 Apr 1;122(7):1017-28. doi: 10.1002/cncr.29871. Review. PMID:26849082

  • Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard E, Eng C, Huntsman S, Torgerson D, Dean M, Winick NJ, Martin PL, Camitta BM, Bowman WP, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui C-H, Evans WE, Relling MV, Loh M, and Yang JJ. Genome-wide Association Study Identifies a Novel Susceptibility Locus at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations. J Natl Cancer Inst. 2013 May 15;105(10):733-42. doi: 10.1093/jnci/djt042. Epub 2013 Mar 19.

  • Loh ML, Zhang J, Mullighan CG, Harvey RC, Roberts K, Payne-Turner D, Kang H, Wu G, Chen X, Becksfort J, Edmonson M, Buetow KH, Carroll WL, Chen I-Ming, Devidas M, Gerhard DS, Bowman P, Larsen E, Raetz E, Smith M, #Downing JR, #Willman CL, and #Hunger, SP. .# (# senior authors who contributed equally to the work). Tyrosine kinome sequencing of high risk pediatric acute lymphoblastic leukemia: A Report from The Children’s Oncology Group TARGET Project. Blood. 2012 Dec 4. Epub ahead of print. PMID 23212523.

  • Yang JJ, Cheng C, Devidas M, Cao X, Campana D, Yang W, Fan Y, Neale G, Cox N, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Reaman GH, Carroll WL, Loh M, Evans WE, Pui C-H, Hunger SP, and Relling MV. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Blood. 2012 Nov 15; 120(20):4197-204. Sept 24 Epub ahead of print. PMID 23007406.

  • Parham RR, Geng H, Chen Z, Chan LN, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, and Müschen M. SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 2012 Nov. 14. Epub ahead of print. PMID 23152540.

  • Maude SL, Tasian SK, Vincent T, Hall JW, Sheen C, Roberts KG, Seif AE, Barrett DM, Chen IM, Collins JR, Mullighan CG, Hunger SP, Harvey RC, Willman CL, Fridman JS, Loh ML, Grupp SA, and Teachey DT. Targeting Jak1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood. 2012 Oct 25; 120(17):3510-8. Epub ahead of print 2012 Sept. 6. PMID: 22955920.

  • Gallagher RE, Moser BK, Racevskis J, Poiré X, Bloomfield CD, Carroll AJ, Ketterling RP, Roulston D, Schachter-Tokarz E, Zhou D, Chen IM, Harvey R, Koval G, Sher DA, Feusner JH, Tallman MS, Larson RA, Powell BL, Appelbaum FR, Paietta E, Willman CL, and Stock W. Treatment-influenced Associations of PML-RARα Mutations, FLT3 Mutations and Additional Chromosome Abnormalities in Relapse Acute Promyelocytic Leukemia. Blood. 2012 Sept 6; 120(10):2098-108. PMID: 22734072.

  • Roberts KG, Morin R, Zhang J, Hirst M, Zhao Y, Su, X, Chen S-C, Payne-Turner D, Churchman M, Chen X, Harvey R, Kasap C, Yan C, Becksfort J, Finney RP, Teachey D, Maude S, Tse, K, Moore R, Jones S, Mungall K, Birol I, Edmonson M, Hu Y, Buetow KE, Chen I-M, Carroll WL, Wei L, Ma J, Kleppe M, Levine R, Garcia-Manero G, Larson E, Shah N, Devidas M, Reaman G, Smith M, Paugh S, Evans WE, Grupp S, Jeha S, Pui C-H, Gerhard DS, Downing JR, Willman CL, Loh M, Hunger SP, Marra M, Mullighan CG. Novel genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell. 2012. Aug 14; 22(2):153-66. PMID: 22897847.

  • Lo MC, Peterson LF, Yan M, Cong X, Jin F, Shia WJ, Matsuura S, Ahn EY, Komeno Y, Ly M, Ommen HB, Chen IM, Hokland P, Willman CL, Ren B, and Zhang DE. Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. 2012. Blood Aug 16; 120(7):1473-84. PMID: 22740448.

  • Tasian SK, Doral MY, Mullighan CG, Borowitz MJ, Wood BL, Chen IM, Harvey RC, Gastier-Foster JM, Willman CL, Hunger SP, and Loh ML. Aberrant JAK/STAT and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemias. 2012. Blood. July 26; 120(4):833-42. PMID: 22685175.

  • Epler KE, Padilla D, Phillips GK, Crowder P, Castillo RE, Wilkinson DC, Wilkinson BS, Burgard CA, Kalinich RM, Townson JL, Chackerian B, Willman CL, Peabody DS, Wharton W, Brinker CJ, Ashley CE, Carnes EC. Delivery of ricin toxin A-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers. Adv Healthcare Materials. 2012 Epub April 2. In press for May 14. (Cover Art). PMCID:PMC3332089.

  • Chen IM, Harvey RC, Mullighan CG, Gastier-Foster J, Wharton W, Kang H, Borowitz MJ, Camitta BM, Carroll AJ, Devidas M, Pullen DJ, Payne-Turner D, Tasian SK, Reaman GH, Bowman WP, Carroll WL, Loh M, Winick N, Hunger SP, and Willman CL. Outcome modeling with CRLF2, IKZF1, JAK and minimal residual disease in pediatric acute lymphoblastic leukemia: A Children’s Oncology Group Study. Blood. 2012 April 12; 119(15):3512-22. Epub 2012 Feb 24. PMID: 22368272.

  • Ashley CA, Carnes EC, Epler KE, Padilla DP, Phillips GK, Carroll NK, Castillo RE, Wilkinson DC, Wilkinson BS, Burgard CA, Kalinich RM, Townson JL, Chackerian B, Willman CL, Peabody DS, Pestev DN, Wharton W, and Brinker CJ. Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers." ACS Nano. 2012 Mar 27; 6(3):2174-88. Epub Feb 14. (ACS Nano Cover Art; Commentary: Protocells prove their worth in drug delivery. ACS Nano. 2012 March 27; 6(3):1830-1832). PMCID:PMC3332089.

  • Xu H, Cheng C, Devidas D, Pei D, Fan Y, Yang W, Neale G, Scheet P, González-Burchard E, Torgerson DG, Eng C, Dean M, Antillon F, Winick NJ, Martin PL, Willman CL, Camitta BM, Reaman GH, Carroll WL, Loh M, Evans WE, Pui CH, Relling MV, Hunger SP, and Yang JJ. ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment of childhood acute lymphoblastic leukemia. J Clinical Oncol. 2012 Mar 1; 30(7):751-7. Epub 2012 Jan 30. PMID: 22291082.

  • Kang H, Wilson CS, Harvey RC, Chen I-M, Bedrick EJ, Murphy M, Atlas SR, Devidas M, Carroll AJ, Robinson BW, Heerema N, Hilden JM, Dreyer ZE, Camitta B, Winick N, Carroll WL, Felix CA, Reaman GH, Stam RW, Valchecci M, Pieters R, Hunger SP, and Willman, CL. Gene expression profiling reveals genes predictive of outcome in infant acute lymphoblastic leukemia (ALL) and distinctive age-related expression profiles: A COG Study. Blood. 2012. 119:1872-1881. Epub 2011, Dec. 30. PMID: 22210879.

  • Zhang J, Mullighan CG, Harvey RC, Wu G, Chen X, Edmonson M, Buetow KH, Carroll WL, Chen I-M, Devidas M, Gerhard DS, Loh ML, Reaman GH, Relling MV, Camitta BM, Bowman WP, Smith MA, Willman CL#, Downing JR#, and Hunger SP.# (# joint senior authors). Key pathways are frequently mutated in high risk B-precursor childhood acute lymphoblastic leukemia: A report from the Children’s Oncology Group NCI TARGET Project. Blood 2011. Sep 15; 118(11):3080-7. Epub 2011, Jun 16. PMID: 21680795.

  • Ashley CE, Carnes EC, Phillips GK, Durfee PN, Buley M, Padilla DP, Phillips B, Carter MC, Willman CL, Brinker CJ, Chackerian B, Wharton, W, and Peabody DS. Cell-specific delivery of diverse cargos by bacteriophage MS2 virus-like particles. ACS Nano. 2011. Jul 26; 5(7):5729-45. Epub 2011, June 7. (ACS Nano Cover Art). PMID: 21615170.

  • Ashley CE, Carnes CE, Phillips GK, Padilla D, Brown PA, Hanna TN, Liu J, Comyford B, Carroll N, Jiang X, Spielman I, Willman CL, Petsev DN, Evans DG, Chackerian B, Wharton W, Peabody DS, and Brinker CJ. Protocells – a universal nanocarrier for targeted delivery of multicomponent cargoes to cancer. Nature Materials. 2011. May; 10(5):389-97. Epub: 2011, April 17. PMID: 21499315. (Nature Materials Cover Art; Commentary: Irvine, Darrell J. News and Views: One Nanoparticle, One Kill. Nature Materials. 2011 May; 10(5):342-3).

  • Yang JJ, Cheng C, Devidas M, Cao X, Yang W, Campana D, Fan Y, Neale G, Cox N, Scheet M, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui CH, Evans WE, and Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nature Genetics. 2011 March; 43(3):237-41. Epub: 2011 Feb 6. PMID: 21297632. (Commentary: Channock S.J. A twist on admixture mapping. Nature Genetics. March 2011. 43(3):178-179).

  • Powell BL, Moser B, Stock W, Gallagher RE, Willman CL, Stone RM, Rowe JM, Coutre S, Feusner JH, Gregory J, Couban S, Appelbaum FR, Tallman MS, and Larson RA. Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. 2010. Blood Nov. 11; 116(19):3751-7. PMID: 20705755.

  • Harvey RC, Wang X, Dobbin KK, Davidson GS, Bedrick EJ, Chen IM, Atlas SR, Kang H, K Ar, Wilson CS, Wharton W, Murphy M, Devidas M, Carroll AJ, Borowitz MJ, Bowman WP, Mullighan CG, Downing JR, Yang JJ, Carroll WL, Camitta B, Reaman GH, Smith M, Hunger SP, and Willman CL. Identification of novel cluster groups in pediatric high risk B-precursor acute lymphoblastic leukemia by gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood. 2010 Dec. 2; 116(23):4874-64. Epub 2010 Aug. 10. PMID: 20699438. (Commentary: Kulozik, A.E. Taking Childhood Leukemia Personally. Blood. December 2, 2010. 116(23):4737-8).

  • Harvey RC, Mullighan CG, Chen IM, Wharton W, Mikhail FM, Carroll AJ, Kang H, Liu W, Dobbin KK, Smith MA, Carroll WL, Devidas M, Bowman WP, Camitta BM, Reaman GH, Hunger SP, Downing JR, and Willman CL. Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood. 2010. Jul 1; 115(26):5312-21. Epub. Feb 4. PMID: 20139093.

  • Kang H, Chen IM, Wilson CS, Bedrick EJ, Harvey RC, Atlas SR, Hunger SP, Devidas M, Wang X, Murphy M, K Ar, Wharton W, Borowitz MJ, Bowman WP, Bhojwani D, Carroll WL, Camitta B, Reaman GH, and CL Willman. Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Blood. 2010. Feb 18; 115(7):1394-405. Epub 2009 Oct. 30. PMID: 19880498. Commentary on this Work: Higgs, R. Gene Expression Profiling is Prognostic in ALL Cases Nature Reviews Clinical Oncology. May 2010. 7:239.

  • Mullighan CG, Phillips L.A., Collins-Underwood R, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Carroll AW, Heerema NA, Basso G, Pesson A, Pui CH, Raimondi S, Hunger SP, Downing JR, Carroll WL, and Rabin KR. Rearrangement of CRLF2 in B-progenitor and Down Syndrome-associated acute lymphoblastic leukemia. Nature Genetics. 2009. Nov. 41(11):1243-6. PMID:19838194.

  • Gregory J, Kim H, Alonzo T, Gerbing R, Woods W, Weinstein H, Shepherd L, Schiffer C, Appelbaum FR, Willman CL, Wiernik P, Rowe J, Tallman M, and Feusner J. Treatment of children with acute promyelocytic leukemia: results of the first North American Intergroup Trial INT0129. Pediatric Blood Cancer. 2009. Dec 53(6): 1005-10. PMID: 19743516.

  • Treviño LR, Yang W, French D, Hunger SR, Carroll WL, Devidas M, Willman CL, Neale G, Downing J, Raimondi S, Pui CH, Evans WE, and Relling MV. Germline genomic variations associated with childhood acute lymphoblastic leukemia. Nature Genetics. 2009. Sep 4; 41(9):1001-5. PMID: 19684603.

  • Wray J, Williamson EA, Sheema S, Lee SH, Libby E, Willman CL, Nickoloff JA, and Hromas R. Metnase mediates chromosome decatenation in acute leukemia cells. Blood. 2009. Aug 27; 114(9):1852-8. PMID: 19458360 (Blood Cover Art).

  • Mullighan CG, Zhang J, Harvey RC, Schulman BA, Phillips LA, Su X, Devidas M, Atlas SR, Chen IM, Clifford R, Gerhard D, Carroll WL, Reaman GH, Smith M, Downing JR, Hunger SP, and Willman CL. 2009. JAK mutations in high risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 2009. Jun 9; 106(23):9414-8. PMID: 19470474.

  • Yang J, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds S, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui CH, Devidas M, Bowman WP, Camitta BM, Willman CL, Davies SM, Borowitz MJ, Carroll WL, Hunger SP, Relling MV. 2009. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA. 2009 Jan 28; 301(4):393-403. PMID: 19176441.

  • Mullighan CG, Su X, Zhang J, Radke I, Phillips LAA, Miller CB, Ma J, Liu W, Cheng C, Shulman BA, Harvey RC, Chen IM, Clifford RJ, Carroll WL, Reaman G, Bowman WP, Devidas M, Gerhard DS, Wang W, Relling MV, Shurtleff SA, Campana D, Borowitz MJ, Pui CH, Smith M, Hunger SP, Willman CL, and Downing JR. 2009. Deletion of IKZF1 (IKAROS) is associated with poor prognosis in acute lymphoblastic leukemia. New England J Medicine. 2009 Jan 29; 360(5):470-480. PMID: 19129520.

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