Faculty


Research Interests:

  • GTPases as targets of small molecules therapeutics for ovarian cancer and genetic diseases
  • Cellular & molecular basis of autosomal dominant polycystic kidney disease
  • Renal stem cells
  • Interrelationships between membrane trafficking, signaling cell polarity and disease pathology
  • Molecular mechanisms of Rab GTPases and lipid signaling in membrane trafficking

Education Interests:

  • Skill building and career development through cross-training in research and education
  • Development of training programs that build diversity in research and education

Education and Certification Information

Post-Doctoral Training Fellowship:
Cell Biology Programme
European Molecular Biology Laboratory
Heidelberg, FRG
(1986-1991)

Ph.D.:
Biochemistry
University of California
Los Angeles, California
(1985)

B.S.:
Biochemistry
University of Massachusetts
Amherst, Massachusetts
(1979)


Selected Publications:

2012-present:

  • Hong, L., Z. Surviladze, S.R. Kenney, G.K. Phillips, D. Simpson, C.E. Schroeder, J. Nöth, E. Romero, T. Buranda, A. Waller, O. Ursu, J.J. Strouse, J.E. Golden, J. Aubé, L.G. Hudson, L.A. Sklar and A. Wandinger-Ness. (2013) Identification and Characterization of a Cdc42 GTPase Selective Inhibitor. J Biol. Chem. 288:1135-49. PMC3542998. (Impact factor: 4.77). Article chosen for feature by SciBX. UNM Cancer Center Press Release and under consideration for Nature News and Views feature.

  • Herbert, B.-S., B.R. Grimes, W.M. Xu, M. Werner, C. Ward, S. Rossetti, P. Harris, E. Bello-Reuss, H.H. Ward, C. Miller, V.H. Gattone, C.L. Phillips, A. Wandinger-Ness and R. Bacallao. (2013) A Telomerase Immortalized Human Proximal Tubule Cell Line with a Truncation Mutation (Q4004X) in Polycystin-1. PLoS One, 8(1):e55191. PMC3557233 (Impact factor: 4.09).

  • BasuRay, S., S. Mukherjee, E. Romero, M.N.J. Seaman and A. Wandinger-Ness. (2013) Rab7 Mutants Associated with Charcot-Marie-Tooth Disease Cause Delayed Growth Factor Receptor Transport and Altered Endosomal and Nuclear Signaling. J. Biol. Chem. 288:1135-1149. PMC3542998 [Available on 2014/1/11]. (Impact factor: 4.77). Cited by Faculty of 1000: Li G: F1000Prime Recommendation of [BasuRay S et al., J Biol Chem 2013, 288(2):1135-49]. In F1000Prime, 22 Jan 2013 F1000Prime.com/717970694#eval793469245.

  • Stein, M-P., M. Müller and A. Wandinger-Ness. (2012) Commandeering Rabs allows bacterial pathogens to establish intracellular niches. Invited review. Traffic: doi: 10.1111/tra.12000. 13:1565-1588. Special Series on Pathogen-Host Cell Interactions. PMC3530015 [Available on 2014/2/17]

  • Agola, J.O., L. Hong, Z. Surviladze, T. Buranda, O. Ursu, A. Waller, J.J. Strouse, D.S. Simpson, C.E. Schroeder, J.E. Golden, T.I. Oprea, J. Aubé, L.A. Sklar and A. Wandinger-Ness. (2012) A Competitive Nucleotide Binding Inhibitor: In vitro Characterization of Rab7 GTPase Inhibition. ACS Chemical Biology. 7:1095-108. PMC3440014 [Available on 2013/6/15]. (Impact factor: 6.446)

  • Chavez, M., C. Buhr, W. Petri, A. Wandinger-Ness, D. Kusewitt and L. Hudson. (2012) Differential Downregulation of E-cadherin and Desmoglein by Epidermal Growth Factor. Dermatology Research and Practice. 2012:309587. PMC3270554.

Links:

Search PubMed:

Angela Wandinger-Ness on PubMed