Alexandre Chigaev, Ph.D.

photo of Alexandre Chigaev

Associate Professor

Email: achigaev@salud.unm.edu
Lab Website: The Chigaev Laboratory


Interests:

  • Immune cell signaling and adhesion
  • Drug discovery and repositioning (repurposing)
  • Stem cell mobilization and hematological malignancies
  • Real-time measurement of signaling pathways and ligand-receptor interactions

Education and Certification Information

Postdoc
Pathology
University of New Mexico, Albuquerque, NM
and Los Alamos National Laboratory, Los Alamos, NM
2000-2003

Postdoc
Biochemistry
Weizmann Institute of Science
Rehovot, Israel
1998-2000

Ph.D.
Biology
Moscow State University
Moscow, Russia
1990-1994

B.S. and M.S.
Biology
Saratov State University
Saratov, Russia
1983-1990


Selected Publications:

  1. Zucchetto A, Tissino E, Hartmann TN, Chigaev A, Del Poeta G, Colombatti A, Gattei V. Ibrutinib Inhibits VLA-4-Dependent Adhesion in CLL-Letter. Clin Cancer Res. 2016 Jul 1;22(13):3410-1. doi: 10.1158/1078-0432.CCR-16-0050. No abstract available. PMID:27371631

  2. Perez D, Simons PC, Smagley Y, Sklar LA, Chigaev A. A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3',5'-Cyclic Adenosine Monophosphate Efflux. Methods Mol Biol. 2016;1439:227-44. doi: 10.1007/978-1-4939-3673-1_15. PMID:27316999

  3. Perez DR, Smagley Y, Garcia M, Carter MB, Evangelisti A, Matlawska-Wasowska K, Winter SS, Sklar LA, Chigaev A. Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia. Oncotarget. 2016 Jun 7;7(23):33960-82. doi: 10.18632/oncotarget.8986. PMID:27129155

  4. Perez DR, Smagley Y, Garcia M, Carter MB, Evangelisti A, Matlawska-Wasowska K, Winter SS, Sklar LA, Chigaev A. Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia. Oncotarget. 2016 Apr 25.;7(23):33960-82. PubMed PMID: 27129155.

  5. Zucchetto A, Tissino E, Hartmann TN, Chigaev A, Del Poeta G, Colombatti A, Gattei V. Ibrutinib Inhibits VLA-4-Dependent Adhesion in CLL-Letter. Clin Cancer Res. 2016 Jul 1;22(13):3410-1. doi: 10.1158/1078-0432.CCR-16-0050. PubMed PMID: 27371631.

  6. Perez D, Simons PC, Smagley Y, Sklar LA, Chigaev A. A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3',5'-Cyclic Adenosine Monophosphate Efflux. Methods Mol Biol. 2016;1439:227-44. doi: 10.1007/978-1-4939-3673-1_15. PubMed PMID: 27316999.

  7. Ganghammer S, Hutterer E, Hinterseer E, Brachtl G, Asslaber D, Krenn PW, Girbl T, Berghammer P, Geisberger R, Egle A, Zucchetto A, Kruschinski A, Gattei V, Chigaev A, Greil R, Hartmann TN. CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21. Oncotarget. 2015 May 20;6(14):12048-60. PubMed PMID: 25895128; PubMed Central PMCID: PMC4494922.

  8. Chigaev A, Sklar LA, Schrader R, Stephens N, Raissy H, Winter SS. The evaluation of thioridazine as a hematopoietic progenitor cell mobilizing agent in healthy human subjects. J Clin Pharmacol. 2015 May;55(5):512-6. doi: 10.1002/jcph.448. Epub 2015 Feb 4. PubMed PMID: 25511480; PubMed Central PMCID: PMC4420020.

  9. Hong L, Chavez S, Smagley Y, Chigaev A, Sklar LA. Relationship of light scatter change and Cdc42-regulated actin status. Cytometry B Clin Cytom. 2016 Nov;90(6):499-505. doi: 10.1002/cyto.b.21223. PMID:25641607

  10. Chigaev A. Does aberrant membrane transport contribute to poor outcome in adult acute myeloid leukemia? Front Pharmacol. 2015 Jul 2;6:134. doi: 10.3389/fphar.2015.00134. eCollection 2015. PubMed PMID: 26191006; PubMed Central PMCID: PMC4489100.

  11. Chigaev A, Smagley Y, Haynes MK, Ursu O, Bologa CG, Halip L, Oprea T, Waller A, Carter MB, Zhang Y, Wang W, Buranda T, Sklar LA. FRET detection of lymphocyte function-associated antigen-1 conformational extension. Mol Biol Cell. 2015 Jan 1;26(1):43-54. doi: 10.1091/mbc.E14-06-1050. Epub 2014 Nov 5. PubMed PMID: 25378583; PubMed Central PMCID: PMC4279228.

  12. Chigaev A, Smagley Y, Sklar LA. Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization. BMC Immunol. 2014 Oct 31;15:52. doi: 10.1186/s12865-014-0052-1. PubMed PMID: 25367365; PubMed Central PMCID: PMC4221689.

  13. Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, Golden JE, Aubé J, Hudson LG, Buranda T, Sklar LA, Wandinger-Ness A. Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem. 2013 Mar 22;288(12):8531-43. doi: 10.1074/jbc.M112.435941. Epub 2013 Feb 4. Erratum in: J Biol Chem. 2014 Mar 7;289(10):6837. PubMed PMID: 23382385; PubMed Central PMCID: PMC3605667.

  14. Chigaev A, Sklar LA. Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion. Front Immunol. 2012 Aug 2;3:242. doi: 10.3389/fimmu.2012.00242. eCollection 2012. PubMed PMID: 22876249; PubMed Central PMCID: PMC3410440.

  15. Chigaev A, Sklar LA. Overview: assays for studying integrin-dependent cell adhesion. Methods Mol Biol. 2012;757:3-14. doi: 10.1007/978-1-61779-166-6_1. Review. PubMed PMID: 21909902; PubMed Central PMCID: PMC3805125.

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