Aaron K. Neumann, Ph.D.

photo of Aaron Neumann

Assistant Professor

Email: akneumann@salud.unm.edu
Lab Website: The Neumann Laboratory


Interests:

  • Cell biology and signal transduction of fungal pathogen sensing via C-type lectins in dendritic cells and macrophages
  • Nanostructure in the fungal call walls and innate immunoreceptors with respect to its impact on the success or failure of anti-fungal immunity
  • Quantitative live cell optical microscopy techniques to investigate host-microbe interactions between primary human innate immune cells and fungal pathogens
  • Application of light-activated conjugated polyelectrolyte antimicrobials to treat and prevent fungal infection in clinical settings such as wound care and medical device contamination
  • Development of rapid, culture free technologies for diagnosis of infectious diseases.

Education and Certification Information

Post Doctoral Fellowship
University of North Carolina at Chapel Hill, School of Medicine
Advisor-Dr. Ken Jacobson
2005-2011

Ph.D.
Immunology
University of Pennsylvania, School of Medicine
Philadelphia, PA
2005

B.S.
Chemistry and Biology
King College, Bristol, TN.
1993-1997


Selected Publications:

  • Graus MS, Neumann AK, Timlin JA. Hyperspectral fluorescence microscopy detects autofluorescent factors that can be exploited as a diagnostic method for Candida species differentiation. J Biomed Opt. 2017 Jan 1;22(1):16002. doi: 10.1117/1.JBO.22.1.016002.PMID: 28056142 PMCID: PMC5216876 [Available on 2018-01-05]

  • Pappas HC, Sylejmani R, Graus MS, Donabedian PL, Whitten DG, Neumann AK. Antifungal Properties of Cationic Phenylene Ethynylenes and Their Impact on β-Glucan Exposure. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4519-29. doi: 10.1128/AAC.00317-16. PMID:27161628

  • Lin J, Wester MJ, Graus MS, Lidke KA, Neumann AK. Nanoscopic cell-wall architecture of an immunogenic ligand in Candida albicans during antifungal drug treatment. Mol Biol Cell. 2016;27(6):1002-14. Epub 2016/01/23. doi: 10.1091/mbc.E15-06-0355. PubMed PMID: 26792838; PubMed Central PMCID: PMC4791122.

  • Itano MS, Graus MS, Pehlke C, Wester MJ, Liu P, Lidke KA, Thompson NL, Jacobson K, Neumann AK. Super-resolution imaging of C-type lectin spatial rearrangement within the dendritic cell plasma membrane at fungal microbe contact sites. Front Phys. 2014 Aug;2. pii: 46. PubMed PMID: 25506589; PubMed Central PMCID: PMC4262399.

  • Graus MS, Pehlke C, Wester MJ, Davidson LB, Steinberg SL, Neumann AK. A new tool to quantify receptor recruitment to cell contact sites during host-pathogen interaction. PLoS Comput Biol. 2014 May 29;10(5):e1003639. doi: 10.1371/journal.pcbi.1003639. eCollection 2014 May. PubMed PMID: 24874253; PubMed Central PMCID: PMC4038466.

  • Liu P, Wang X, Itano MS, Neumann AK, de Silva AM, Jacobson K, Thompson NL. Low copy numbers of DC-SIGN in cell membrane microdomains: implications for structure and function. Traffic. 2014 Feb;15(2):179-96. doi: 10.1111/tra.12138. Epub 2013 Dec 3. PubMed PMID: 24313910; PubMed Central PMCID: PMC4104803.

  • Itano MS, Steinhauer C, Schmied J, Forthmann C, Liu P, Neumann AK, Jacobson K, Tinnefeld P, Thompson NL, 2012. Super-Resolution Imaging of C-Type Lectin and Influenza Hemagglutinin Nanodomains on Plasma Membranes using Blink Microscopy. Biophys J, 102(7):1534-1542. PMCID: PMC3318115

  • Liu P, Wang X, Itano MS, Neumann AK, Thompson NL, Jacobson K, 2012. The Formation and Stability of DC-SIGN Microdomains Require its Extracellular Moiety. Traffic, 13(5): 715-726, PMCID:PMC3365552

  • Itano MS, Neumann AK, Liu P, Zhang F, Gratton E, Parak WJ, Thompson NL, Jacobson K. DC-SIGN and influenza hemagglutinin dynamics in plasma membrane microdomains are markedly different, Biophys J, 2011; 100(11): 2662. PMCID: PMC3117154

  • Neumann AK, Itano MS, Jacobson K. Understanding lipid rafts and other related membrane domains, F1000 Biol Rep, 2010; 2: 31. PMCID: PMC2894464

  • Neumann AK, Thompson NL, Jacobson K, 2008. Distribution and Lateral Mobility of DC-SIGN on Immature Dendritic Cells – Implications for Pathogen Uptake, J Cell Science, 121(5): 634-43. http://jcs.biologists.org/content/121/5/634.long

  • Neumann AK & Jacobson K. A Novel Pseudopodial Component of the Dendritic Cell Anti-fungal Response: the Fungipod, PLoS Pathog, 6(2): e1000760. PMCID: PMC2820528

Search PubMed:

Aaron K. Neumann on PubMed